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Long-acting gut-hormone agonists as a class tend to show tachyphylaxis of the gastric-emptying effect it attenuates with continued dosing even as central appetite suppression persists
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Tiered pricing and patient-assistance programs have yet to impact uptake in price-sensitive geographies significantly
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Ageing Research Reviews, 42 , 14-27
These findingsoriginating from landmark trials such as EMPA-REG OUTCOME, LEADER, and SUSTAIN-6have led to substantial revisions in international guidelines from the European Society of Cardiology, American College of Cardiology, and American Heart Association, which now recommend the use of SGLT2i or GLP-1 RAs, often in conjunction with metformin
