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As a result, the FDA advises against using it during pregnancy unless the benefits to the mother significantly outweigh the risks to the fetus, a decision typically made only in extreme situations where no safer alternative exists

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5 How They Compare: Mechanism and Clinical Evidence Both NAC and glutathione ultimately support the same biological outcome -- higher intracellular glutathione and lower oxidative burden -- but they operate at different points in the pathway and carry different clinical evidence profiles