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Meanwhile, those who stopped the medication began to regain weight, emphasizing the importance of ongoing treatment to sustain weight loss results

If your main goal is the highest average weight loss seen in large studies, GLP-1based medications lead the category, with semaglutide showing about 14.9% average loss at 68 weeks and tirzepatide showing up to about 20.9% at 72 weeks (dose-dependent)

How GLP-1 Works GLP-1 is a natural hormone made by your body

Comparing muscle loss across different weight loss methods Perspective helps

Stimulates insulin release when blood sugar rises and reduces glucagon secretion, helping maintain stable glucose levels throughout the day