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Research mechanism GLP-1 receptor activation in pancreatic -cells, hypothalamus, brainstem Glucose-dependent insulin secretion Delayed gastric emptying Central appetite suppression via hypothalamic and brainstem receptors Trial data summary STEP 1 trial (Wilding et al., NEJM 2021): mean body weight reduction of 14.9% at 68 weeks with weekly 2.4mg dosing
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That said, these molecules also have useful roles, such as fighting off infection
How quickly do GLP-1 medications start working