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High levels are associated with heart disease, hardening of the arteries, diabetes, and colon cancer

Gastrointestinal side effects are the most frequently reported adverse reactions to GLP-1 receptor agonists, affecting a significant proportion of patients, particularly during initial treatment or dose escalation

Work from our and other groups showed that LAC also modulates acetylation of NF-B/p65 subunit, which potentiates the transcriptional activity of NF-B member to increase transcription of the Grm2 gene encoding for the mGlu2 receptor in hippocampus and prefrontal cortex of FSL rats [30, 36]

doi: 10.1172/JCI94601 33 KoethR

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M., and Gillatt, D