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Leukemia 29, 12531266
The five subtypes (MC1R to MC5R) are class A G-protein-coupled receptors that signal principally through Gs and adenylyl cyclase to raise intracellular cAMP, and the conserved His-Phe-Arg-Trp core of alpha-MSH is the message sequence recognised by the binding pocket
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While it was ruled unlikely that the event was related to the peptide, the investigators decided to halt any future trials
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