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The most common side effects are pain and swelling at the injection site

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Adverse effects are primarily gastrointestinal: Nausea, vomiting, and diarrhea occur in about 59 percent of patients

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The boxplots of metabolite concentrations were created using the "geom_boxplot" and "facet_wrap" modules of R studio software

In contrast, while the dose-response relationship between -cell responsiveness to glucose (expressed as the slope of the linear relation between insulin secretion rate and the glucose concentration) and GLP-1 levels in circulation is partially impaired a phenomenon referred as GLP-1 resistance (62) a therapeutic infusion of GLP-1 at a pharmacological dose can restore -cell insulin secretion responsiveness to glucose levels comparable to those observed in nondiabetic individuals (62)