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It maintains vascular endothelial function, reduces arterial stiffness, and enhances blood pressure regulation, thereby diminishing the risk of cardiovascular events such as myocardial infarction and stroke

in colorectal cancer, tumor-derived lactate promotes macrophage H3K18la to repress RAR transcription and elevate IL-6, which activates STAT3/c-Myc signaling in cancer cells to reinforce M2-like TAM polarization (70)

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