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68 The balance among MMPs and TIMPs (tissue inhibitors of metalloproteinases) are important for the regulation of pathogenesis of Matrix metalloproteinases like MMP-1 (interstitial collagenase), MMP-3 (stromelysin-1) and MMP-13 (collagenase 3) plays an essential part in osteoarthritis based on their capability to cleave components of the ECM in articular cartilage

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Reported side effects are typically mild and transient: BPC-157: Nausea (rare), mild fatigue in the first week, minor injection site redness TB-500: Mild lethargy during the loading phase, transient head rush immediately after injection, injection site discomfort Combined stack: No documented synergistic toxicity in preclinical or clinical observational data The more significant risks relate to sourcing and administration rather than the peptides themselves

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