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The unexpected activity can be explained by the formation of variable amounts of disulfide-bridged PfGrx C32S/C88S homodimers and potential Diamide-modified monomers, summarized as PfGrx C32S/C88S (SX), as revealed by non-reducing SDS-PAGE (Fig
This includes starting with big doses, then keeping up with smaller ones
doi: 10.1007/s00344-022-10700-7 52 ImperialeD.LencioniG.MarmiroliM.ZappettiniA.WhiteJ
Further analysis also revealed a difference in variance in HIF1a + Tbr2 + co-labeled INPs (Fig
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