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Research has revealed that the E5 oncoprotein of HPV16 is associated with cervical lesions and may play a role in carcinogenesis by affecting cell proliferation and differentiation as well as apoptosis [29]

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As well as chemical targeting, enzymatic targeting is another challenging strategy and cyst(e)inase-mediated depletion of serum cysteine and cystine pools has already been demonstrated to suppress the growth of tumours in different animal models

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