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They may differ in efficacy, safety, risk, and side-effect profiles from commercially available or FDA-approved drugs

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Among them, Vitamin B12 plays a crucial role in red blood cell formation, DNA synthesis, and nerve function

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It is: Slowing the titration schedule (staying at 2.5 mg for 6 to 8 weeks instead of 4) Eating smaller, more frequent meals Avoiding high-fat foods that delay gastric emptying further Using ginger, vitamin B6, or prescription antiemetics (ondansetron, metoclopramide) during the adaptation window In severe cases, stepping back down to the previous tolerated dose These interventions address the mechanism

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The decline is gradual rather than sudden, which researchers note is consistent with a compound that functions as an ongoing signaling factor in tissue maintenance rather than one tied to a single life stage or event

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Therapeutic Goods Administration (TGA)

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