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In vitro, NKG2D CAR-T cells selectively eliminate senescent fibroblasts induced by different stresses as well as in vivo, in mice and non-human primate aged models where the effects of this cell therapy are significant without any toxicity observed

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In stroke research, for example, models that incorporate hypertensive or diabetic phenotypes have demonstrated significantly altered responses to neuroprotective interventions compared to normotensive controls, underscoring the critical importance of patient-specific biological contexts [575]

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Neurogenin 2 has an essential role in development of the dentate gyrus