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1000 g IM daily or every other day for 12 weeks, then 1000 g once weekly for 48 weeks

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Experimental groups consisted of 20 animals each, and the overall design of the study is presented in Figure 1

Sleepwake cycle In the 1990s, a number of trials were carried out into the effects of B12 on circadian rhythm and the sleepwake cycle, but no more recent studies have been published on this topic

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