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Risk ratios (RR) for hospitalization for heart failure estimates according to direct (DPP-4 inhibitors, GLP-1RA and SGLT-2 inhibitors against placebo) and indirect (DPP-4 inhibitors vs GLP-1RA or SGLT-2 inhibitors, and GLP-1RA vs SGLT-2 inhibitors) comparisons
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gastrointestinal distress
Furthermore, SGLT2-i interference with either generation or effect of ANG II at renal tissues site possibly plays a significant role in this setting
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