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However, because this distal site of action that cannot utilize tubuloglomerular feedback to ameliorate glomerular hyperfiltration [95, 96], DPP-4 inhibition does not appear to exert early benefits on renal function in type 2 diabetes
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c , In molecular dynamics simulation of the PF-06372222-bound GLP-1R crystal structure, the ionic lock hydrogen bond network is preserved
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Any use outside the FDA-approved indication is considered off-label and should involve informed consent, individualized evaluation, and ongoing medical monitoring
