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Additionally, preclinical research suggests GLP-1 agonists may inhibit nuclear factor-kappa B (NF-B) signaling, a central pathway in inflammatory responses
These findings suggest that a GST tag is not an authentic TG2 substrate but instead is accidentally crosslinked by TG2 during cell lysate incubation
UGTs: UDP-glycosyltransferases
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Additionally, some novel GLP-1s hold promise for improved tolerability, as evidenced by Structure Therapeutics phase 2 data for GSBR-1290, which demonstrated encouraging results in terms of AEs and discontinuation rates
