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2-moderate changes
Providers who push faster titration may get patients to therapeutic doses sooner, but they also lose more patients to intolerable side effects
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Polymyxins are antimicrobial peptides that interact with the lipopolysaccharide (LPS) moiety of the membrane of Gram-negative bacteria and induce divalent cation displacement, resulting in destabilization of the membrane, loss of integrity, and cell death 3,4,5
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