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Choline is the major precursor of betaine, and it is used by the kidneys to maintain water balance and by the liver as a source of methyl-groups for methionine formation

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Older adults A 2015 review suggests that adults over the age of 60 may be more likely to have a vitamin B12 deficiency

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Beyond direct antioxidant activity, GSH functions as an obligatory cofactor for a family of enzyme systems that are central to cellular defence: glutathione peroxidases (GPx), which reduce peroxides and lipid hydroperoxides using GSH as the reducing substrate