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Measurement of Dnmt activity showed an increased trend in HFD-fed mice liver, and Tet hydroxylase activity significantly inversed
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Two reasons: (1) similar half-lives (~7 days each) make a single weekly protocol pharmacokinetically practical, and (2) the GLP-1 + amylin combination engages two complementary metabolic pathways
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Exposure per milligram is higher, particularly in lighter East Asian users, while the smaller fat reserve makes a 75:25 fat-to-lean split more consequential
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