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Effects of a 14-week community health program of exercise and learning/education in older adults: a single-arm pre-post comparison study
These numbers are unprecedented for a non-surgical, pharmacological intervention and notably the weight-loss curve had not fully plateaued at 48 weeks, suggesting that even greater reductions might occur with longer exposure
In addition, individuals who may be vitamin K deficient due to liver failure, those with a propensity to bleed (e.g., bleeding peptic ulcers), and those with inherited bleeding disorders (e.g., hemophilia) or a history of hemorrhagic stroke, should not take -tocopherol supplements without close medical supervision because of the increased risk of hemorrhage (119, 128)
Additionally, the enhanced stability of niosomes compared to other vesicular carriers, due to the chemical stability of non-ionic surfactants against oxidation and hydrolysis, ensures that more of the administered dose reaches the systemic circulation intact [122,123]
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