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Rarely, allergic reactions like itching or rash can occur, and excessive or prolonged use may strain the kidneys or liver, especially in those with pre-existing conditions

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Ignited by the observation of a rapid antidepressant effect of the glutamate N -methyl-D-aspartate (NMDA) receptor antagonist ketamine, the glutamate system has emerged as a leading focus for novel drug discovery for depression and other mood disorders

Molecular mechanisms of the non-coenzyme action of thiamin in brain: biochemical, structural and pathway analysis