Third, GLP-1s target dopamine receptors in the brain, reducing what is called food noise, i.e., the constant mental math about eating that can occupy a lot of brain space, particularly for patients who have long struggled with weight problems and the attendant self-criticism and shame-based messaging from society (and from doctors) conflating weight and worthiness
doi:10.1210/en.2003-0723
Known side effects (class effects similar to other GLP-1 medications) Gastrointestinal issues (very common): Nausea: 38-43% of participants vs 11% placebo Diarrhea: 33-35% vs 13% placebo Vomiting: 20-21% vs 0% placebo Constipation: 22-25% vs 9% placebo Decreased appetite: 18-19% vs 9% placebo These are expected with incretin-based therapies and typically improve over time as your body adjusts
What Happens If You Take Too Much and How to Recognise Dosage Excess Lipotropic injections are generally well-tolerated, but methionine excess produces recognisable symptoms
Dunham's life no longer revolves around her next meal Dunham also noticed changes to her appetite and relationship with food
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