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While their underlying mechanisms of action remain incompletely understood, it is clear that the common denominator between GLP-1R agonists and bariatric surgery is that they suppress food intake by targeting the brain
The practical implications are still emerging, but the directional trend is toward faster generic entry relative to patent expiry dates
However, the strength of evidence for these findings was very low
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Of note, glomerular hyperfiltration could be exacerbated by other hormonal changes associated with scarce glucose control, such as high glucagon levels [49, 51]
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