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Without intentional resistance training during the medication phase, a meaningful portion of the weight lost is lean muscle rather than fat

Participants randomized to the 2.4 mg weekly dose lost an average of 15.3 kg (33.7 lb), compared to 2.6 kg in the placebo group

The American Diabetes Association recommends it as a first-line treatment for patients with type 2 diabetes who are at high risk of cardiovascular disease, and it is also used for blood glucose and obesity management, chronic kidney disease, and metabolic dysfunction-associated steatohepatitis (MASH)

They may start with a lower dose and increase it gradually while monitoring for acid reflux symptoms

This short-term model suits patients needing rapid weight reduction for a specific event or as a bridge to lifestyle modification, but does not address chronic weight management