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Both semaglutide and tirzepatide are effective for weight loss, but studies show that tirzepatide (Mounjaro, Zepbound, etc) generally causes more weight loss than semaglutide (Ozempic, Wegovy, etc) due to its added GIP receptor activity in addition to GLP1
Dehydration secondary to gastrointestinal side effects (vomiting and diarrhea) can cause fluid and electrolyte imbalances that may trigger compensatory tachycardia that patients perceive as palpitations
Key Takeaway: Proper site rotation and choosing a fatty area like the abdomen or thigh ensures the medication is absorbed correctly and minimizes the risk of skin irritation or tissue buildup
While these medications can help with weight loss, stopping them often leads to weight regain which in turn increases the likelihood of restarting therapy
Insulin is also an injectable medicine that is used to treat diabetes by controlling the level of glucose in the blood
Lancet 2010;375:14471456
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