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Much of the earliest clinical and animal data was generated with the crude extracts (epithalamin, thymalin), whereas most of the mechanistic molecular work nuclear penetration, DNA binding, gene-expression assays was done with the defined synthetic peptides

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Proton pump inhibitors such as omeprazole, prescribed by your physician, are the most effective pharmacological option if reflux persists beyond 4 to 6 weeks at meaningful intensity

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