However, the protective effect was strongest in patients with obesity and absent in non-obese patients, strongly suggesting that benefits are heavily confounded by weight loss and metabolic improvement rather than direct gut anti-inflammation (101)
Side effects and practical notes Orlistat causes loose stools, urgency, and oily spotting, especially after fatty meals
We have a program in MASH, in the liver, the LIVERAGE program, plus a robust data-generation program to come over the next couple of years, because we want to bring a comprehensive package for metabolic health, said Neeraja Balachander, who oversees the companys cardio-renal-metabolic portfolio
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Periodic body composition assessment with DXA or bioelectrical impedance helps track changes in lean mass versus fat mass and guides adjustments to diet, protein targets, and resistance training