In Lau et al., gastrointestinal disorders occurred in 4163% of cagrilintide participants (0.34.5 mg) versus 32% of placebo, primarily nausea at 2047% versus 18% [5]
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Loading protocols use 250-500 mg daily for 3-5 days
A degraded product may still show a peptide-like HPLC peak but at an incorrect retention time or with additional impurity peaks
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In patients receiving cytostatic therapy, the increase in PS exposure coincided with a rise in RBC volume, which is atypical for eryptosis, typically associated with cell shrinkage