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Interestingly, knockdown of AKT2 but not AKT1 increased ~3.5-fold of MEK1/2 phosphorylation compared with the scrambled siRNA transfected cells (Fig

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Today, it is well known that necroptosis can be triggered by TNF, TNF-related apoptosis-inducing ligand (TRAIL), and Fas ligand, which activate the death receptor-mediated apoptosis pathway and lead to necroptosis when CASP8 activation is prevented by pharmacological caspase inhibitors (e.g., Z-VAD-FMK) or genetic depletion of fas-associated via death domain (FADD) (47, 48)