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Its also possible that these associations have nothing to do with vitamin B12 and rather that it is an innocent bystander
Side effects appear to be infrequent and mild in most reported cases, and may include: Temporary injection site reactions (with subcutaneous administration) Mild headache in some individuals Vivid dreams often considered a sign of enhanced REM sleep activity Occasional mild gastrointestinal discomfort DSIP does not appear to suppress respiratory function or cause the cognitive impairment sometimes associated with sedative-hypnotic drugs
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also stated that MTX-induced oxidative stress may cause glomerular and tubular damage by causing MTX accumulation in the kidney (Reference Li, Abe and Yamakawa42)
