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In 2023, the STEP-HFpEF trial showed that semaglutide, a once-weekly long-acting GLP-1 RAs, significantly improved exercise capacity, enhanced quality of life, and notably reduced body weight while mitigating inflammation over 52 weeks in obese patients with HFpEF compared to placebo [9]

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References Papers of particular interest, published recently, have been highlighted as: Of importance Of major importance Centers for Disease Control and Prevention