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Fennel (Foeniculum vulgare) is another herb with potential therapeutic effects in PCOS due to its phytoestrogenic properties, which may weakly mimic estrogen and influence metabolic and hormonal regulation [205]

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Lipoic acid stimulates cAMP production via the EP2 and EP4 prostanoid receptors and inhibits IFN gamma synthesis and cellular cytotoxicity in NK cells

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131 This is consistent with the data in humans showing that a low-protein diet (5E% protein) increased plasma FGF21 concentrations by 171% over 4 weeks despite caloric overfeeding

As the field matures, more formalized certification pathways will likely develop