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Healthcare (Basel)
GLP-1's primary functions include: Enhancing insulin secretion in response to glucose Suppressing inappropriate glucagon release Delaying gastric emptying Promoting satiety and reducing appetite Understanding GLP-1's role is fundamental when evaluating whether dietary interventions, such as allulose consumption, might influence incretin hormone activity or complement GLP-1-based therapies
Zhao C, Zhang Y, Liu H, Li P, Zhang H, Cheng G
For people with T2D, a phase 2 trial showed that 12 weeks of efinopegdutide achieve up to 7.9% WL (compared to 0.7% WL with placebo) without actual improvement in HbA1c [78]
Combining tirzepatide with hormone therapy adds roughly 35% more weight loss per Mayo Clinic ENDO 2025, especially relevant for hormonal belly fat redistribution
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