Nicotinamide Mononucleotide Increases Muscle Insulin Sensitivity in Prediabetic Women. Science , vol
What stood out: CagriSema achieved 23.0% weight loss at 84 weeks (efficacy estimand) Tirzepatide achieved 25.5% On the treatment-regimen estimand, weight loss was 20.2% vs 23.6% Primary endpoint not met: CagriSema did not demonstrate non-inferiority vs tirzepatide on weight loss at 84 weeks Why this matters This is a reminder that in obesity pharmacotherapy, very effective and best-in-class are not the same conversation
Weekly administered agonists performed better compared to daily ones
Among the most frequently rejected foods are fatty dishes, deli meats, sweets, coffee and alcohol, while new preferences include fruits, lean proteins and plant-based items, adds IFF, which has developed a suite of AI-refined, consumer-tested product concepts to help food and beverage manufacturers optimize portfolios for users on these medications
If semaglutide is still providing health benefitslike lowering blood sugar in people with type 2 diabetes or helping with heart healthdoctors may still recommend staying on it, even if weight loss has slowed
Intravenous cetirizine versus intravenous diphenhydramine for the treatment of acute urticaria: a Phase III randomized controlled noninferiority trial