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2.3 Information sources and search strategy Three databases (PubMed, Embase, and Scopus) were searched up to 15 July 2024

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GLP-1 is an incretin hormone produced by the intestinal L-cells in response to nutrient stimulation ( Figure 1 , this broad anatomical distribution of GLP-1R enables GLP-1 and its receptor agonists to modulate multiple interconnected metabolic and neuroendocrine pathways