INTRODUCTION The production of reactive oxygen (ROS) and nitrogen (RNS) species is unavoidable under aerobiosis, especially at the level of electron transfer chain reactions for ROS or via enzymatic processes for RNS
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Importantly, this catalytic tetrad is conserved among all the seleno-GPxs (GPx1, GPx2, GPx3, GPx4, and GPx6) characterized from human (Table 1