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Highlights of Prescribing Information: Zepbound (tirzepatide) Injection, for subcutaneous use

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115 As CAN progresses, patients may experience resting tachycardia, exercise intolerance, orthostatic hypotension, and silent myocardial ischemia

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The metabolic interplay between the vascular and skeletal systems thus emerges as a therapeutic focal point, in which CIT enhances endothelial responsiveness, leucine promotes muscle anabolic processes, and exercise serves to integrate both systems through hemodynamic and molecular stimuli