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In animal studies, some GLP-1s have shown harmful effects on developing foetuses, which has led to caution around use in pregnancy and breastfeeding
However, as both can influence gut motility and the microbiome, their combined effects on IBS symptoms should be observed and managed accordingly
Wu W, Chen W, Liu S et al (2021) Beneficial relationships between endophytic Bacteria and Medicinal plants
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Both GLP1-RA and DPP4i groups had an average of 2.3 (SD 4.4 and 4.1) inpatient admissions and 7.8 (14.1 and 12.9) ED visits during the baseline period which had an average duration of 132 months (~11 years) in both groups
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![Structures of (a) GLP-1, (b) GIP and (c) tirzepatide [19, 88, 90]](https://www.researchgate.net/publication/370926483/figure/fig4/AS:11431281185432337@1693619320519/Structures-of-a-GLP-1-b-GIP-and-c-tirzepatide-19-88-90-Amino-acids-are.png)
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