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FOXO4-DRI acts as a competitive inhibitor of this interaction binding directly to the transactivation domain 2 (TAD2) of p53, displacing FOXO4, and allowing phosphorylated p53 to be exported from the nucleus and directed to mitochondria, where it activates BAX, triggers caspase-3 cleavage (via the p53/BCL-2/Caspase-3 signalling pathway), and drives cell-intrinsic apoptosis

"Thymosin beta4: a multi-functional regenerative peptide." Expert Opin Biol Ther

Enhanced brain delivery of liposomal methylprednisolone improved therapeutic efficacy in a model of neuroinflammation

The math behind reconstitution is straightforward

Quantification of Iba1 + cells was performed using ImageJ software, with results expressed as fluorescence intensity per mm 2 or mean fluorescence intensity (MFI)

Aug 13 2013;62(7):569-576