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Initially, only patients with four weight-related health problems and a BMI of 40 or more (adjusted for ethnicity) will be eligible to access tirzepatide (Mounjaro) through primary care settings in England 41

Retatrutide (5 mg) is a synthetic peptide designed for laboratory research on metabolic regulation and hormone receptor signaling

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GLP-1 receptor agonists mimic these effects, promoting satiety (feeling full), suppressing glucagon (a blood sugar-raising hormone), and enhancing insulin sensitivity