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A small fraction is oxidized (CYP2E1 NAPQI)

Arch Neurol 69:836841 Hardan AY, Fung LK, Libove RA, Obukhanych TV, Nair S, Herzenberg LA, Frazier TW, Tirouvanziam R (2012) A randomized controlled pilot trial of oral N-acetylcysteine in children with autism

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NAC acts as a mediator of glutathione production and protects cells from damage

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Attenuation of cisplatin ototoxicity by otoprotective effects of nanoencapsulated curcumin and dexamethasone in a Guinea pig model