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Heat above 25C can also potentially be a problem, although less so

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Problems due to lack of cell division in fast dividing tissues: Anaemia, or any cytopaenia (including leucocytes, lymphocytes, platelets) Mouth ulcers, malabsorption, diarrhoea due to macrocytosis and atrophy of the intestinal mucosa as demonstrated by Foroozan and Trier

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Studies suggest 10-20 times higher tissue concentrations compared to topical application of equivalent amounts