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This may, in part, explain why the neuroprotective strategies trialled to date that are directed at a single target have generally been unsuccessful at producing clear benefits (Supplementary Table 2)

In like manner, while caudatin presents anti-inflammatory and neuroprotective properties in Alzheimers disease models, translation to humans will be more complex and we ultimately need to consider whether there are ways caudatin can pass the selective permeability of the blood-brain barrier

Elsevier: Amsterdam, The Netherlands, 2012

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