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Additionally, TMAO has been demonstrated to worsen reduced glucose tolerance, limit hepatic insulin signaling, and incite inflammation in adipose tissue in vivoall essential elements of the atherosclerotic pathway [76]
Cardiovascular Outcomes Semaglutide has demonstrated cardiovascular benefits, including a reduction in major adverse cardiovascular events (MACE) such as heart attack and stroke in patients with type 2 diabetes at high cardiovascular risk
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If Phase 3 trials complete successfully and Lilly submits an NDA in late this year, FDA approval could come by mid to late next year
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