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GPR40 is coupled to both Gq and Gs proteins and in vivo studies suggest how signaling through both these cascades elicits the most powerful GLP-1 secretion (258)

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Three GLP-1 RAs (Victoza, Ozempic, and Trulicity) have been approved in the U.S

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doi: 10.1038/nri.2016.70 19 ChiH

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GLP-1 is also secreted by a small population of neurons in the hindbrain (Richard et al., 2015)

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