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After day 28, the semaglutide molecules may begin breaking down, reducing the drug's effectiveness and potentially creating safety concerns

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7 If a patient meets these criteria, it is recommended that the addition of an agent with evidence for cardiovascular or renal risk reduction be considered independent of the patients current A1C or A1C target

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These Phase 3 RCTs currently in progress and in the pipeline should provide further clarity on the long-term safety and overall effect of once-weekly subcutaneous retatrutide