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FOXO4-DRI is a large peptide (~5382 Da, 48 amino acids) with a critical structural modification: the D-Retro-Inverso (DRI) design uses D-amino acids in reversed sequence to confer protease resistance while maintaining the 3D spatial arrangement needed for target binding

For the NAC rescue experiment, mice received intraperitoneal administration of 200 mg/kg of body weight NAC (A105422, Aladdin) in phosphate-buffered saline (pH 7.4) every second day for two weeks

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Rachman, J., Barrow, B

At low doses, radiation exhibits some beneficial effects in reducing oncogene-induced carcinogenesis ( Increase of endogenous reactive oxygen species (ROS) is one of the important factors that damage the body