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Therefore, increased nutrient influx for these commensal bacteria coupled with decreased acid secretion, barrier breakdown, and alteration of the intestinal adaptive immune system would lead to proliferation of these bacteria, resulting in the occurrence of small intestinal bacterial overgrowth (SIBO) and the development of food intolerances [294, 295]

Furthermore, current immunomodulatory therapies, including immunosuppressants and biologics, remain predominantly palliative

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