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Modeling monogenic diabetes using human ESCs reveals developmental and metabolic deficiencies caused by mutations in HNF1A

Gostine remains actively engaged in clinical practice

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Some patients report a mild boost in alertness or increased urination

Pharmacokinetic Profile Route of Administration Subcutaneous Dosing Frequency Once weekly Half-Life 5 days Route of Administration : Subcutaneous injection Dosing Frequency : Once weekly Half-Life : ~5 days Formulation : Lyophilized powder for reconstitution Formulation & Handling Store at 20C Protect from light and moisture Reconstitute with sterile water

Concurrently, astrocyte dysfunction leads to reduced synthesis of KYNA